Anaemia, fatigue and weight loss in CKD
Why tiredness during treatment is not always the medicine, and the blood tests we check before blaming the dose.
Written by Professor Mohammed Mahdi Althaf
Medically reviewed by Professor Mohammed Mahdi Althaf, Consultant Nephrologist · 3 August 2026
Overview
Anaemia (low red blood cell count) is common in CKD and is a major cause of fatigue. When starting a weight loss journey, it is vital to distinguish between "weight loss fatigue" and "renal anaemia."
Why it's done and who it helps
- Monitoring Hb levels: We track your Haemoglobin (Hb) to ensure your energy levels support your exercise goals.
- Iron and EPO: Many CKD patients require iron supplements or Erythropoietin (EPO) injections to manage anaemia.
- Identifying Nutrient Deficiencies: Rapid weight loss can sometimes lead to low B12 or iron if dietary intake is poor.
UK Kidney Association Standards
The UKKA recommends maintaining Hb levels between 100-120 g/L for most CKD patients. If your Hb is below 100, you may feel too tired to exercise, which will hinder your weight loss progress.
Clinical Monitoring
Professor Mohammed Mahdi Althaf reviews your full blood count alongside your weight logs to ensure your fatigue isn't masking a treatable clinical condition.
Preparing for your appointment
Why am I so tired on the jab?
Initial fatigue is common as your body adjusts to fewer calories, but persistent, worsening fatigue needs a blood test.
Can I still lose weight if I have anaemia?
Yes, but treating the anaemia first often makes the process much more successful and sustainable.
References
- UK Kidney Association (UKKA) Anaemia in CKD Guideline
- NICE NG203: Chronic kidney disease: assessment and management
- British Society for Haematology Guidelines
This article is general patient information reviewed by a consultant nephrologist. It is not individual medical advice; treatment decisions are made at a face-to-face consultation.
